Excerpt from Fallout Wiki:
They appear to be identical in power to a Mini nuke, in a throwable form.
Characters with Loose Cannon may be unable to escape the blast, even if thrown max distance. This becomes particularly difficult if you also have Splash Damage. Obviously, these should not be used in tight, confined spaces. The grenades are best utilized in open areas or places with hard cover such as hotel rooms, where it's possible to escape the explosion.
In appearance they look similar to a normal frag grenade with the exception of a painted white cross on them.
3 Holy Frag Grenades are located in the basement of the church in the east part of Camp Searchlight, guarded by 2 golden geckos. It will only be available to players that have the Wild Wasteland trait. Players without the trait will only find two mini nukes in the location instead.
The cult hit Monty Python and the Holy Grail started the Holy Hand Grenade joke, which was previously featured in Fallout 2. Specifically, this weapon is a reference to the Holy Hand Grenade of Antioch. Operating instructions along with the numbers 5 (crossed out) and 3 is another reference to the aforementioned movie. #courier #Fallout #frag #greanade #hand #holy #holy_grail #mini #monty_python #new #nuke #vegas #victor